Four hypertrophic scars on the ventral side of a rabbit’s ear 4 weeks’ post-wound.
Hypertrophic Scar Formation in Rabbits
At CBI, an example of a standard Hypertrophic Scar Formation study, we first create a circular lesion with removal of the perichondrium elicits a proliferative fibrosis resulting in scar formation on the rabbit ear.
• This lesion can be measured and effects of test article determined
• Typical study setup:
• 6 weeks with dosing at day of wound formation
• After formation of scar (~3 weeks) with 3-4 weeks treatment
• With 2-3x weekly assessments and followed by histopathology for each
• Test article may be applied topically or intralesion injection
• Vehicle and test article applied to lesions
About Hypertrophic Scar Formation Studies
At CBI, we have a bold vision – Hypertrophic scars are benign and not harmful to a person’s general health. They do not develop into skin cancer. A hypertrophic scar will often regress completely between 6 months and 3 years after it first appears.
About Histopathologic Scores
Histopathologic scoring is a tool by which semi-quantitative data can be obtained from tissues. Initially, a thorough understanding of the experimental design, study objectives and methods are required to allow the pathologist to appropriately examine tissues and develop lesion scoring approaches.
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Contact Comparative Biosciences, Inc. to discuss a scientific study program for all Studies and Services.
Comparative Biosciences, Inc. · Phone: 408.738.9260
– CUSTOM HYPERTROPHIC SCAR STUDIES UPON REQUEST –