Ocular Efficacy Models | Comparative Biosciences, inc

Ocular Models of Pharmacology and Efficacy

Comparative Biosciences, Inc. a premier ocular research CRO, provides a large variety of validated discovery and translational preclinical ophthalmic research studies including ocular efficacy, pharmacology, or in vivo indications. Our ophthalmic models include macular degeneration, retinopathies, inflammation, dry eye, glaucoma, and degenerative disease. We also have capabilities in ocular device implantation and evaluation. Further, we have capabilities in corneal epithelial and endothelial assessments. CBI scientists are available to discuss these models in more detail. We are also willing to work with our sponsors to develop unique or customized models.

CBI provides special assessment techniques including, OCT (See our OCT video), ERG, gonioscopy, ocular ultrasound, tonometry, laser photocoagulation, slit lamp, funduscopy, retinal angiography, pachymetry, Schirmer and phenol red thread test, hypoxic or hyperoxic chambers.

CBI is also happy to be able to develop new, customized and novel ocular models in collaboration with our sponsors and to address special regulatory issues presented by the regulators.

We are happy to provide further information and validation data on our models upon request.

. For a full overview of our Ocular Studies, please download CBI Technical Bulletin: CBI-Technical Bulletin.Ocular

Validated Efficacy Ophthalmic Models available at CBI include:

Models of Angiogenesis and Macular Degeneration

Choroidal neovascularization in mice, rats and pigs (laser-induced)
Choroidal neovascularization in rabbits (laser-induced)
Oxygen-induced retinopathy in mice and rats
VEGF-induced choroidal neovascularization in rabbits
Streptozotocin-induced retinopathy
Senescent knockout mouse model of macular degeneration

Models of Inflammation

Melanin-antigen associated anterior auto-immune uveitis in Lewis rats
IRBP-antigen associated posterior inflammation in rodents
LPS-induced acute inflammation in rabbits and rodents
Ovalbumin-induced immune mediated inflammation in rabbits
F48/80-induced acute inflammation in rabbits
Corneal infection

Models of Glaucoma

Laser-induced episcleral cautery for glaucoma in rats
Chymotrypsin-induced glaucoma in rabbits

Models of Dry Eye

Concanavalin A-induced dry eye in rabbits
Botulinum-induced dry eye in mice
Scopolamine-induced dry eye in mice
Atropine-induced dry eye in rabbit and mice

Device Implantation

Intraocular stents for glaucoma or drug delivery
Corneal rings
Punctal plugs
Artificial lens insertion or removal
Corneal surgery
Corneal debridement
Intraocular implants
Corneal wound healing
Endothelial damage or disease indications

Models of Corneal Injury, Inflammation and Healing

Heptanol-induced corneal erosion in rabbits
Suture-induced inflammation in rodents
Corneal incision
Bacterial or infectious models of ocular inflammation

Models of Ocular Degeneration

MNU-induced retinitis pigmentosa
Vitreal detachment

Contact Lens Testing

Ocular Implants

Intraocular stents
Punctal plugs,
Drug delivery systems
Glaucoma treatment

Hyper Oxygenation

Low or high oxygen chambers to induce oxygen-induced retinopathy of prematurity or pulmonary bronchodysplasia

Stem Cell Treatment and Administration

Vitreal Detachment and Vitreal Integrity

Ocular Histopathology and Immunohistochemistry

GLP histopathology for ocular toxicology studies: ocular examination of globe and adenexal structures
Histopathologic examination of ocular tissues from research studies
Ocular pharmacology models
Ocular immunohistochemistry
Retinal whole mount

Custom or Specialized Models

CBI is happy to design and develop novel models of ocular pharmacology and to address special issues related to ocular toxicology.

Ocular Assessments

CBI provides special techniques including, OCT (See our OCT video), ERG, ocular ultrasound, gonioscopy, tonometry, laser photocoagulation, slit lamp, funduscopy, pachymetry, Schirmer test, phenol red thread test, hypoxic or hyperoxic chambers, retinal angiography, device implantation, lens removal or insertion, whole mount preparation, ocular histology and immunohistochemistry and ocular photography.