Marimastat-induced musculoskeletal syndrome in rats
Matrix Metalloproteinase Inhibitors (MMP) are potential anti-neoplastics with antitumor and anti-angiogenic effects. A broad spectrum inhibitor of MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, Marimastat administration is associated with a painful joint condition… Read More
Heymann Nephritis: Immune-mediated FX-1A-induced glomerular nephritis in rats
Immune-mediated FX-1A-induced glomerular nephritis in rats is an excellent translational model of immune mediated membranous glomerular nephritis in humans. Administration of sheep antibody to rat proximal tubular epithelial cell brush border antigen… Read More
Metabolic syndrome and insulin resistance in horses
Insulin resistance (pre-diabetes) or metabolic syndrome is a disorder not only common in humans, dogs and cats, but also in horses and for very similar reasons! It is characterized by obesity, regional… Read More
Optical Coherence Tomography: OCT at CBI
Why should companies come to CBI for ocular preclinical studies? Because we simply are the best. We are a smaller company, owned and operated by scientists with a lifetime of experience in… Read More
Optical Coherence Tomography OCT in Rodent Diabetic Retinopathy
One of our most popular uses of OCT is in rodent diabetic retinopathy. We have developed an optimized experimental design with sophisticated OCT, funduscopic and histopathologic determinants to analyze the potential effects… Read More
Benefits Using Optical Coherence Tomography (OCT) for Toxicology Studies
For toxicology studies, OCT is used to follow potential toxic effects of test articles in retinal integrity.… Read More