Immune-mediated FX-1A-induced glomerular nephritis in rats is an excellent translational model of immune mediated membranous glomerular nephritis in humans. Administration of sheep antibody to rat proximal tubular epithelial cell brush border antigen (anti-Fx1A) induces a uniform and severe glomerular nephritis characterized by proteinuria and characteristic histologic changes in the kidney. At CBI, we have optimized and validated the model and we have a robust, uniform model that is suitable for assessment of disease mechanisms and test article activity.
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Images:
. Heymann Nephritis
. Immune mediated FX-1-induced glomerular nephritis
. Urine protein excretion increases beginning about Day 8
